As the story progresses, it becomes clear that this woman is pretty much terrible. She uses all her friends and acquaintances for her own benefit and has no remorse. She even tries to coerce the medical board into taking away Thirteen's license by fabricating a sexual harassment claim!
So, of course, the whole point is to draw a parallel between this woman and House. There's even a scene where he asks her how it is to be a sociopath, and she's all like, "Meh, it's cool. Why you askin'?" And then House gets quiet and leaves.
But he's not a sociopath, you guys! He's just a misanthrope. The subplot this week is House contacting an old med school buddy. If by buddy, you mean, plagiarized on their final paper in a class House didn't like. Ruh-roh! So, they have an awkward lunch, and the dude (his name is Weatherby - how great is that?) reveals that, because he failed that test, he never got his medical license and is now a bag boy at the local grocery store. As if that weren't bad enough, Mr. Weatherby is also about to lose his house because he got an adjustable rate mortgage. Sucks to be you!
So, House gets all sad-like and gives Weatherby a ton of money for his mortgage. It's only then that Weatherby reveals he was just fibbing about all that stuff, and he actually got an A+ on the paper. Oh, and he was a successful orthopedic surgeon until he developed a gambling problem and lost both his license and his house. He just told House all that other stuff to guilt him. But now, House has this check for all this money, and is still trying to foist it on Weatherby. That must mean he has feelings, right? Because he can forgive this dude for lying and still want to bestow great riches upon him? Maybe?
Let's just say the message in all this was not exactly subtle. I'll give you a hint: it has to do with remorse.
But back to Mrs. Sociopath! They finally diagnose her with Wilson's Disease, which can cause sociopathic tendencies, and treat her for it. In addition to her liver/heart/etc. rapidly improving, she also gets her emotions back! Hooray! But now she's been a bitch to everyone in her life for the past 20 years, so most of those emotions are sad ones. Womp, womp.
Will the self-realization that he is not a sociopath make House a better guy? Methinks not, but I'm not concerned. As long as we have more exciting and less predictable patients in the future, Dr. House, I'm along for the ride no matter how badly you treat your friends and coworkers.